Nucleofill — Polynucleotide (PDRN) Rejuvenation
Gel polinukleotida Italia — regenerasi kulit pada tingkat seluler melalui jalur 'lock-and-key' A2A.
- What is Nucleofill?
- The Nucleofill program uses Polynucleotide (PN), extracted from DNA, to stimulate cellular skin repair, naturally enhancing skin structure strength.
Illustrative image, not an actual patient · Individual results vary
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿11,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Not suitable — animal-derived
- Locations
- Siam Square One · BTS Siam Exit 3
Nucleofill adalah gel injeksi polinukleotida (PDRN) yang dibuat oleh Promoitalia (Italia), berlabel CE. Polinukleotida adalah fragmen DNA yang sangat murni yang berasal dari DNA sperma salmon liar; setelah disuntikkan, mereka bertindak sebagai 'kunci' yang pas dengan 'lubang kunci' reseptor adenosin A2A pada permukaan sel, mengaktifkan proliferasi fibroblast, jalur anti-inflamasi, peningkatan mikrosirkulasi, dan perbaikan jaringan.
Empat varian — Medium, Strong, Soft Plus, dan Medium Plus — memungkinkan dokter menyesuaikan konsentrasi dan aliran dengan area tersebut, termasuk zona sensitif seperti bawah mata dan leher.
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦Full-face rejuvenation seeking 'real skin improvement', not volume
- ✦Under-eye dark circles where filler may be risky (Tyndall effect)
- ✦Neck and decolletage rejuvenation
- ✦Acne scars and uneven texture
- ✦Hair-thinning support (scalp injections)
- 01Consultation
Physician selects the appropriate variant (Medium / Strong / Soft Plus / Medium Plus) for your skin condition and treatment area.
- 02Numbing
Topical anaesthetic applied for 20 minutes.
- 03Micro-injection
Polynucleotide gel delivered by multi-point superficial dermal injection across the planned area.
- 04Aftercare brief
Cooling, sun-care and 24-hour activity guidance reviewed.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | Gel polinukleotida Italia — regenerasi kulit pada tingkat seluler melalui jalur 'lock-and-key' A2A. | 45 minutes | Hidrasi instan dalam 1–2 jam; aktivasi metabolik sekitar 48 jam; PDRN dimetabolisme secara bertahap selama 7–15 hari sementara manfaat perbaikan sel terus berlanjut. Protokol yang direkomendasikan: 3–4 sesi, dengan jeda 2–4 minggu, dengan perawatan pemeliharaan setiap 6–12 bulan. Hasil pada tiap individu dapat berbeda. | From ฿11,000 | Full-face rejuvenation seeking 'real skin improvement', not volume |
| Profhilo Bio-Remodelling | Bioremodeling asam hialuronat hybrid. | 45 minutes | Terlihat dalam 4 minggu. Protokol 2 sesi, dengan jeda 1 bulan. Bertahan selama 6 bulan. | From ฿14,000 | Skin laxity |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — Kemurnian 99.8% · Durasi 4–6 bulan · Disetujui Thai-FDA · Merek Botox Korea yang terjangkau. | 15–20 minutes | Onset 3–5 hari; hasil maksimal 10–14 hari; efek bertahan 4–6 bulan. Perawatan rutin setiap 4–6 bulan untuk hasil yang berkelanjutan. | From ฿3,000 | First-time Botox patients (entry tier) |
| Wrinkle-Relax Injection | Injeksi relaksasi kerutan untuk garis dinamis. | 15–20 minutes | Onset 3–7 hari, puncak pada 14 hari. Bertahan selama 3–4 bulan. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | Forehead and frown lines |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
- •Apply gentle moisturiser
- •SPF 50+ broad-spectrum daily — non-negotiable
- •Use only gentle cleanser 5 days
- •Stay hydrated
- •No retinoids / AHA / BHA 7 days
- •Avoid sun exposure 2 weeks
- •No sauna / hot bath 3 days
- •Avoid scrubbing / exfoliating 7 days
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦Cellular-level regeneration via the A2A receptor pathway
- ✦Anti-inflammatory and microcirculation benefits
- ✦Stimulates collagen and elastin without adding HA volume
- ✦Suitable for delicate zones — under-eye, neck, decolletage, scalp
- ✦Four variants tunable to skin condition (Medium / Strong / Soft Plus / Medium Plus)
Yang Diharapkan
Hidrasi instan dalam 1–2 jam; aktivasi metabolik sekitar 48 jam; PDRN dimetabolisme secara bertahap selama 7–15 hari sementara manfaat perbaikan sel terus berlanjut. Protokol yang direkomendasikan: 3–4 sesi, dengan jeda 2–4 minggu, dengan perawatan pemeliharaan setiap 6–12 bulan. Hasil pada tiap individu dapat berbeda.
Hasil individu bervariasi. Hasil bergantung pada usia, jenis kulit, anatomi, gaya hidup, dan kepatuhan pada perawatan pasca. Semua prosedur memiliki risiko; informasi risiko rinci dibahas saat konsultasi dan persetujuan tertulis diperoleh sebelum perawatan apa pun.
Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?
Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.
Ready to talk to our doctor?
Send a photo or describe your concern on LINE — we'll suggest a treatment plan and price range before you visit.
Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
Is Nucleofill safe under the eye?+
Where does the polynucleotide come from?+
How many sessions are recommended?+
Is Nucleofill — Polynucleotide (PDRN) Rejuvenation halal-friendly?+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
Still have questions?
CHAT ON LINEReady to talk it through? Let's begin.
Konsultasi dengan dokter berlangsung sekitar 30–45 menit. Kami akan mendengar dulu — membahas tujuan Anda, lalu memutuskan bersama apakah perawatan tertentu cocok untuk Anda.