Nucleofill — Polynucleotide (PDRN) Rejuvenation
이탈리아의 폴리누클레오틱 제제 — 세포 수준에서 피부 재생을 위한 '락-키' 경로.
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿11,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Locations
- Siam Square One · Ekamai
Nucleofill은 Promoitalia(이탈리아)에서 만든 CE 표기된 폴리누클레오틱(PDRN) 젤 주입제입니다. 폴리누클레오틱은 왜갈색 삼문자 DNA로부터 추출한 고순도 DNA 조각이며, 주입되면 세포 표면의 아데신 A2A 수용체 '락'에 맞는 '키' 역할을 하여 피부 성장세포 증식, 항염작용, 혈류 개선 및 조직 복원을 촉진합니다. 네 가지 변형 — 중간형, 강화형, 소프트 플러스, 중간 플러스 —은 의사가 지역에 맞게 용량과 흐름을 조절할 수 있게 합니다. 이는 특히 눈 아래와 같은 민감한 부위에서도 사용 가능합니다.
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦전면 재생을 원하는 '진짜 피부 개선'을 찾는 분
- ✦필러로 인한 탄력성 위험(타인 효과)이 있는 눈 아래 주름
- ✦목과 가슴의 재생
- ✦흉터와 텍스처 불균형
- ✦모발 얇아짐 지원(두피 주입)
- 01진료
의사는 피부 상태와 치료 영역에 따라 적절한 변형(중간 / 강 / 부드러운 플러스 / 중간 플러스)을 선택합니다.
- 02마취
20분 동안 표면 마취제를 적용합니다.
- 03미세 주입
계획된 영역에 걸쳐 다점 면적 피부 주입으로 폴리누클레오틱 젤을 전달합니다.
- 04후 관리 안내
냉각, 태양 보호 및 24시간 활동 지침 검토
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | 이탈리아의 폴리누클레오틱 제제 — 세포 수준에서 피부 재생을 위한 '락-키' 경로. | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿11,000 | 전면 재생을 원하는 '진짜 피부 개선'을 찾는 분 |
| Wrinkle-Relax Injection | 동적 주름을 완화하는 주름-리클렉스 주입 | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | 미간과 미간 주름 |
| Volume Filler | 하이알루로닉 산으로 볼륨 회복. | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | 턱 볼륨 감소 |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •감성적인 수분크림을 사용하세요
- •SPF 50 이상 광범위한 자외선 차단제를 매일 사용하세요 - 협상 불가
- •약 5일 동안만 부드러운 클렌저를 사용하세요
- •수분 보충에 주의하세요
- •7일 동안 리틴올/아하/비하를 사용하지 마세요
- •2주간은 태양 노출을 피하세요
- •3일 동안 사우나 또는 따뜻한 목욕을 하지 마세요
- •7일 동안 문지름이나 스크럽을 피하세요
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦세포 수준 재생을 위한 A2A 수용체 경로를 통해
- ✦항염증과 微循环利益
- ✦胶原蛋白和弹性蛋白刺激，不增加HA体积填充
- ✦눈 아래, 목, 肩颈, 头皮等敏感区域适用
- ✦피부 상태에 맞춘 네 가지 변형(중간 / 강 / 부드러운 플러스 / 중간 플러스)
What to expect
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?
Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.
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Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
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A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.