Skin Treatment

Nucleofill — Polynucleotide (PDRN) Rejuvenation

Итальянская гель-жидкость полинуклеотидов — регенерация клеточного уровня для улучшения состояния кожи через путь 'ключ-замок' A2A.

Safety summary
Duration
45 minutes
Pain level
Mild — warm tingling
Downtime
Mild redness for a few hours
Contraindications
Pregnancy · active acne flare · isotretinoin within 6 months
Aftercare
SPF 50 + reapply · no exfoliation 5 days · gentle cleanser
N—
О данной процедуре
In one paragraph

Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.

Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).

The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.

Key facts
Category
Skin Treatment
Duration
45 minutes
Downtime
Mild redness for a few hours
Anaesthesia
Topical
Price (from)
From ฿11,000
Brands used
Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
Country of origin
Italy
Regulatory
Thai FDA · CE
Locations
Siam Square One · Ekamai

Nucleofill — это гель-инъекция с полинуклеотидами (PDRN), произведённая компанией Promoitalia (Италия) и сертифицированная CE. Полинуклеотиды представляют собой высокоочищенные фрагменты ДНК, извлечённые из дикой сельди; после инъекции они действуют как 'ключ', который входит в 'замок'

аденинозина A2A на клеточных поверхностях, активируя рост фибробластов, антиинflammatory пути, улучшение микроциркуляции и восстановление тканей. Четыре варианта — Медиум, Сtrength, Софт Плюс и Медиум Плюс — позволяют врачу подобрать концентрацию и поток в зависимости от области,

включая чувствительные зоны, такие как область глаз и шея.

Authenticity & Provenance

Where it comes from, what's inside, who certifies it.

Not halal-compatible

Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.

Country of origin
Italy
Manufacturer
Promoitalia
Brands stocked
Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
Regulatory approvals
EU CEThai FDA / อย.
Animal-derived?
Yes — see disclosure below
Lot-number shown to patient
Yes — every vial, before injection
Disclosure

Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA

PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.

Для кого эта процедура
  • Полно脸部 rejuvenation,寻求‘真实的皮肤改善’而非填充
  • 在眼部下方使用填充剂可能有风险(Tyndall效应)时的色素沉着
  • 颈部和锁骨区域的rejuvenation
  • 痤疮疤痕和纹理不均
  • 头皮脱发支持(头皮注射)
Ваша процедура, шаг за шагом
  1. 01
    Консультация

    Врач выбирает подходящую вариацию (Средний / Сильный / Плюс Сoft / Средний Плюс) в зависимости от состояния вашей кожи и области лечения.

  2. 02
    Нестероидная анестезия

    Применяется топical анестетик на 20 минут.

  3. 03
    Микроинъекция

    Гель полинуклеотидов вводится по многочисленным поверхностным дермальным инъекциям по планируемой области.

  4. 04
    Краткое объяснение после процедуры

    Обзор охлаждения, ухода за кожей и рекомендаций для активности в течение 24 часов.

Why Waleerat at this price

Compare our pricing with anyone — here is what you get that's different.

🩺
Board-certified physicians since 2013

Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.

🔍
Lot-number verification, on demand

Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.

🛡
Thai FDA + US FDA + KFDA + CE approved

Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.

🌐
8-language clinical support

Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.

📍
Two Bangkok BTS-station branches

Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.

Pain level — honest 1-10
3/ 10

Mild — warm tingling

Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.

Open-Box Protocol — see the lot before injection
🔍
Vial opened in front of you

Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.

📷
Lot number photographed if requested

Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.

🛡
Authentic-source-only policy

Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.

📋
Consent form lists the actual product

Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.

Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.

Pre-visit checklist

137 first-time patients asked this in chat — so we wrote it as a checklist.

Avoid before
  • NSAIDs (ibuprofen, aspirin) — 5 days prior
  • Fish oil, vitamin E, garlic, ginkgo — 5 days prior
  • Alcohol — 24 hours prior
  • Heavy facial massage / sauna — 24 hours prior
Bring with you
  • Government photo ID
  • List of current medications + supplements
  • Reference photos (Instagram saves work great)
  • Sunglasses — easy on the eyes after numbing
Concerns this addresses

Click any concern for a detailed explainer.

Compare with alternatives
TreatmentMechanismDurationResults lastPriceBest for
Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page)Итальянская гель-жидкость полинуклеотидов — регенерация клеточного уровня для улучшения состояния кожи через путь 'ключ-замок' A2A.45 minutesImmediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.From ฿11,000Полно脸部 rejuvenation,寻求‘真实的皮肤改善’而非填充
Wrinkle-Relax InjectionИнъекции для разглаживания морщин15–20 minutesOnset 3–7 days, peak at 14 days. Lasts 3–4 months.From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan)Лоб и межбровные линии
Volume FillerВосстановление объема с гиалуроновой кислотой.30 minutesImmediate. Lasts 9–18 months depending on product and area.From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm)Утрата объема щек
Hutox Botulinum Toxin Type A (Korea)Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand.15–20 minutesOnset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results.From ฿3,000First-time Botox patients (entry tier)

Comparative information only — individual results vary. Please consult a licensed physician before deciding.

Before & After
Case shown in private consult
Case shown in private consult
Case shown in private consult
Case shown in private consult
Case shown in private consult
Case shown in private consult

We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.

Aftercare
Do
  • Применять лёгкий увлажняющий крем
  • Спф 50+ каждый день — обязательное требование
  • Использовать только лёгкий очищающий гель в течение 5 дней
  • Поддерживать водный баланс
Don't
  • Не использовать ретиноиды / АХА / БХА в течение 7 дней
  • Относиться к солнечным лучам бережно в течение 2 недель
  • Не посещать сауну или горячие ванны в течение 3 дней
  • Не выскабливать или эколифинговать кожу в течение 7 дней

General guidance — your physician may adapt based on your individual case.

Available at our branches
Flagship · BTS Siam
Siam Square One

Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.

226/1 Rama 1 Road, 2F, Pathum Wan District, Bangkok 10330 — Siam Square One, opposite Siam Paragon · BTS Siam Exit 3
Walking distance to
  • BTS Siam (Exit 3)1m
  • Siam Paragon2m
  • Siam Discovery3m
  • Siam Center3m
  • Siam Kempinski Hotel4m
  • MBK Center5m
  • Chulalongkorn University8m
View on Google Maps →
Japanese-focused · 日本語サポート
Ekamai · 日本人専用窓口

Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.

Ekamai, Bangkok — standalone clinic near BTS Ekamai (Sukhumvit corridor)
Walking distance to
  • BTS Ekamai4m
  • Gateway Ekamai6m
  • Major Cineplex Ekamai6m
  • Park Hyatt Bangkok12m
  • EmQuartier14m
  • EmSphere15m
View on Google Maps →
Преимущества
  • Регенерация клеточного уровня через путь А2А-рецептора
  • Антиспиралитические и микроциркуляционные преимущества
  • Стимулирует коллаген и эластины без добавления объема ХА
  • Подходит для чувствительных зон — под глазами, шее, декольте, лбу

Что ожидать

Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.

Результаты могут отличаться. Ожидаемые результаты зависят от возраста, типа кожи, анатомии, образа жизни и соблюдения рекомендаций по уходу после процедуры. Все процедуры несут в себе риски; подробная информация о рисках рассматривается во время консультации и подписывается согласие на проведение процедуры.

Talk to a physician first

Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?

Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.

Preferred branch

By submitting, you consent to our PDPA-compliant handling of your contact details for the purpose of clinic consultation only.

Готовы поговорить с нашим врачом?

Отправьте фото или опишите проблему в LINE — мы предложим план лечения и диапазон цен до визита.

Чат в LINE
Часто задаваемые вопросы

Real questions from real customers — answered by our physicians

Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran (PDRN จาก Salmon DNA) ฟื้นฟูผิว ลดรูขุมขน สมานแผล · Rejuran I/S/HB Plus ฿12,999/ครั้ง · Rejuran Healer รุ่นใหม่ ฿9,999/ครั้ง ทำ 3–5 ครั้งห่าง 4 สัปดาห์
Rejuran ใต้ตาช่วยเรื่องอะไร+
ฟื้นฟูผิวบางใต้ตา ลดความหมองคล้ำ ลดริ้วรอยเล็ก เหมาะคนไม่อยากฉีดฟิลเลอร์ใต้ตา
Common questions about our clinic

Real questions from real customers — collated from chat conversations.

Are there other promotions?+
Current promotions are refreshed monthly at /promotions. Follow LINE @waleeratclinic for early access to special offers. → View live promos
How much does it cost — is there a promo?+
Starting prices are listed on each service page. Current promos are at /promotions, refreshed monthly. → View live promos
How long does the treatment take?+
Each service varies — topical numbing 30 minutes + procedure 30–90 minutes, totalling 60–120 minutes per session.
Are there side effects?+
Every aesthetic treatment has minor reversible side effects (mild swelling, bruising, redness for 1–7 days). Serious side effects are rare and preventable with a board-certified physician and following aftercare instructions.
Where is the clinic?+
Two Bangkok branches: Siam Square One near BTS Siam (Exit 3) and Ekamai near BTS Ekamai. Open 11:00–19:00 daily.
How long do results last?+
Varies by treatment — Botox 3–6 months · HA filler 9–18 months · thread lift 12–18 months · HIFU/RF 12–24 months · Sculptra 2–3 years · Pico/Drip ongoing per physician guidance.
Does it hurt?+
Topical anaesthetic applied 30 minutes before. Discomfort averages 3–6/10 depending on treatment. Anxiolytics available for anxious patients.
Pregnant or breastfeeding — can I do this?+
All injectable treatments are paused during pregnancy and breastfeeding. Light facials and select vitamin drips remain safe. Always inform your physician.
Can I go home immediately / how many days off work?+
Filler/Botox/laser — go home immediately, no rest needed · thread lift — go home immediately, avoid strenuous activity 2–3 days · HIFU/RF — go home immediately.
Translation support for Chinese / Japanese / Korean / English?+
Chinese + English interpretation at both branches · Japanese/Korean — book 24h ahead. Ekamai branch has Japanese-speaking staff on-site.
How do I book — is rush appointment available?+
Book via LINE @waleeratclinic or website. Rush appointments within 24h subject to availability.
Can I pay by credit card / 0% instalment?+
All credit cards accepted · 0% instalments up to 10 months (KBank/SCB/BBL/Citi) · QR PromptPay supported.

Остались вопросы?

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Begin your consultation

Ready to talk it through? Let's begin.

Бесплатная консультация врача длительностью 30–45 минут предоставляется. Мы внимательно выслушаем Вас — обсудим Ваши цели, а затем совместно определим, подходит ли Вам какая-либо процедура.