Nucleofill — Polynucleotide (PDRN) Rejuvenation
イタリアンポリヌクレオチドジェル — セルレベルの肌再生
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿11,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Locations
- Siam Square One · Ekamai
Nucleofillは、Promoitalia（イタリア）で製造され、CEマークが付いたポリヌクレオチド（PDRN）注入剤です。 ポリヌクレオチドは野生サケの精巣DNAから抽出された高純度なDNA断片であり、注入後は細胞表面のアデノシンA2A受容体「鍵」という役割を果たし、成織細胞の増殖、抗炎症経路、微小循環改善、組織修復などを活性化します。
4つのバリエーション—メディウム、ストロング、ソフトプラス、メディウムプラス—により、医師は濃度と流量を施術部位に合わせることができます。 特に目元や首などのデリケートなゾーンでも使用可能です。
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦全面的な若返りをお求めの方（実質的な肌改善）
- ✦脂肪注入がリスクのある目の下のクマ
- ✦首とデコルテの若返り
- ✦アカネ疤痕と不均一な肌質
- ✦薄毛サポート（頭皮注射）
- 01カウンセリング
医師がお肌の状態や治療部位に合わせて適切なバリエーション（中 / 強 / ソフトプラス / 中強）を選択します。
- 02麻酔処置
計20分間、局所麻酔を適用します。
- 03マイクロインジェクション
多点の表層真皮へのポリヌクレオチドジェルの投与を行います。
- 04アフターケア説明
冷却処置、紫外線対策、24時間間の活動ガイドを確認します。
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | イタリアンポリヌクレオチドジェル — セルレベルの肌再生 | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿11,000 | 全面的な若返りをお求めの方（実質的な肌改善） |
| Wrinkle-Relax Injection | 動的なしわを和らげる注射 | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | 眉間線 |
| Volume Filler | ヒアルロン酸によるボリューム回復。 | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | 頬のボリューム不足 |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •優しい保湿を施す
- •日焼け予防のために毎日SPF50以上の広 espect光日常使用 - 必ずする
- •5日間だけやさしい洗顔料を使用
- •十分な水分補給を行う
- •7日間はレチノイド・AHA・BHAを使用しない
- •2週間は日光に当たらないように注意
- •3日間はサウナや温かい風呂に入らない
- •7日間は scrubbingや去角質を避ける
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦細胞レベルでの再生機能：A2A受容体経路を介した
- ✦抗炎症作用と微小循環改善効果
- ✦コラーゲンとエlastinの刺激、ヒアルロン酸注入なし
- ✦目の下、首、デコルテ、頭皮などの繊細な部位に適応
期待できること
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
個人差があります。結果は、年齢、肌質、体型、ライフスタイル、およびアフターケアへの遵守によって異なります。すべての治療にはリスクが伴います。詳細なリスク情報は相談時に確認され、治療前に署名されたインフォームドコンセントを取得します。
Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?
Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.
ドクターに直接ご相談ください
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Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
まだ気になることがありますか?
LINEで相談するReady to talk it through? Let's begin.
30〜45分の医師によるカウンセリングは無料です。まずはお話を伺い、目標についてご相談させていただき、その後、どのような処置が適しているか、医師とご一緒に決定いたします。