Nucleofill — Polynucleotide (PDRN) Rejuvenation
Gel ng polynucleotid Italiano — pag-ibalik sa cellular na pagkakatawan sa ibaba ng liwayway kautibang A2A 'lock-and-key' pathway.
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿11,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Locations
- Siam Square One · Ekamai
Ang Nucleofill ay isang gel ng polynucleotide (PDRN) na inilathala ni Promoitalia (Italy), na may CE mark. Ang polynucleotides ay mga fragmento ng DNA na maaring pumuri sa wild-salmon sperm DNA; kapag inilatag ito, gumawa ito bilang isang 'key' na naging 'lock' ng adenosine A2A receptor sa ibabaw ng mga cell, nag-aktividad ng pagpapahayag ng fibroblast, mga sentral na anti-inflammatory pathways, pagbabago ng microcirculation at pagbalik-loob ng tissue.
May apat ang mga variant — Medium, Strong, Soft Plus at Medium Plus — na may patakaran sa konseptro at fluency ng doktor upang matukoy ang area, kabilang pa rin ang mabubuting mga zona tulad ng under-eye at neck.
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦Paggamit para sa pagkakatawan ng buong face na may 'real skin improvement', walang volume
- ✦Para sa under-eye dark circles kung may risk ang filler (Tyndall effect)
- ✦Paggamit para sa pagkakatawan ng neck at decolletage
- ✦Paggamit para sa mga acne scars at uneven texture
- ✦Paggamit para sa support ng hair-thinning (injections sa scalp)
- 01Konsultasyon
Ang doktor ay tumanda sa appropriate na hakbang (Medium / Strong / Soft Plus / Medium Plus) para sa kondisyon ng iyong skin at lugar ng pagkakataon.
- 02Numbing
Ang topical anestesiya ay inilagay upang mapasadya ang 20 minuto.
- 03Micro-injection
Ang gel ng Polynucleotide ay inilagay sa multi-point superficial dermal injection sa plano na lugar.
- 04Briefing sa pagpapahayag ng aftercare
Ang paggamit ng cooling, sun-care at 24-hour activity guidance ay ipinapakita.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | Gel ng polynucleotid Italiano — pag-ibalik sa cellular na pagkakatawan sa ibaba ng liwayway kautibang A2A 'lock-and-key' pathway. | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿11,000 | Paggamit para sa pagkakatawan ng buong face na may 'real skin improvement', walang volume |
| Wrinkle-Relax Injection | Pagsasalakip ng mga Linyeng Dinamiko sa Klinikang Luxo ng Bangkok | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | Mga linya ng paglalakbay |
| Volume Filler | Paggawa ng Volumen sa Pagsasakay ng Hyaluronic Acid. | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | Cheek volume loss |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •Mag-apply ng mabubuting humyidizador
- •5 araw, gamitin lamang ang mabubuti na pagsisiyasat
- •Paggamit ng tubig para sa pagkain — hindi kailangani
- •Maging matatagpuan sa tubig
- •Huwag gumamit ng retinoids / AHA / BHA 7 araw
- •2 semble, huwag i-expose sa hangin
- •Huwag humingi ng sauna / malalim na bath 3 araw
- •Huwag ipaglaban / paglilipat 7 araw
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦Paggamit ng A2A receptor pathway sa pamamagitan ng Polynucleotide (PDRN) para sa regenerasyon ng mga cell
- ✦Anti-inflammatory at pagpapahayag ng mikro-kirculasyon
- ✦Stimulasyon ng collagen at elastin na walang kailangan ng HA volume
- ✦Tandaan ang mga mahina na rehiyon—baba ng mata, lawa, decolletage, scalp
- ✦Mga hakbang na tunay sa kondisyon ng skin (Medium / Strong / Soft Plus / Medium Plus)
What to expect
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?
Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.
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A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.