E40 Bio-Revitalizing HA (5 BRP) — Italian Hybrid HMW
Italian Hybrid High-Molecular-Weight HA — 5 Bio-Revitalization Points · Lift + Tighten + Hydrate · No-downtime · since 2015.
The E40 Bio-Revitalizing HA treatment utilizes non-cross-linked High-Molecular-Weight Hyaluronic Acid (HMWHA) to stimulate ECM remodeling at the fibroblast level, resulting in instant lifting and skin tightening. This treatment is suitable for individuals seeking to improve skin hydration and elasticity.
The 5 BRPs deliver these effects in a 30-minute session, with minimal downtime. The price range begins at ฿8,500.
Available at the Waleerat Clinic in Bangkok. CE-marked and Thai-FDA approved for safety and efficacy.
E40 (Vitapharm / Medixa, Italy) is a Hybrid High-Molecular-Weight Hyaluronic Acid bio-revitalizer using non-cross-linked HMWHA technology. The signature 5 BRPs (Bio-Revitalization Points) deliver three simultaneous effects in a single session: instant lifting, skin tightening, and intense hydration — all by triggering ECM (Extracellular Matrix) remodelling at the fibroblast level.
CE-marked, FDA-source raw material, and ISO-certified manufacture. Marketed in Asia under Vitapharm.
Developed in Italy since 2015.
Where it comes from, what's inside, who certifies it.
Hyaluronic acid is bio-fermented from Streptococcus zooepidemicus (bacterial source), not animal-derived. Major HA brands (Juvederm, Restylane) confirmed halal-compatible by LPPOM-MUI fatwa.
- Country of origin
- Italy
- Manufacturer
- Medixa srl (distributed in Asia by Vitapharm)
- Brands stocked
- E40 · 5 BRP · Bio Revitalizing HA
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- No — synthetic / bio-fermented source
- Lot-number shown to patient
- Yes — every vial, before injection
Italian-made Hybrid HMW HA bio-revitalizer. Non-cross-linked. CE marked since 2015. Distributed in Asia by Vitapharm.
- ✦Patients seeking lift + tighten + hydration in one session
- ✦Photoaged skin needing dermal restoration
- ✦First-time bio-revitalizer patients (gentler than Profhilo, no downtime)
- ✦Pre-event glow-up (skin firmness visible in 24h)
- 01Consultation
Physician assesses skin laxity and maps the 5 BRP injection points per side.
- 02Topical numbing (optional)
Cream applied 20 minutes prior — many patients skip and tolerate well.
- 035 BRP injections
5 precise micro-injections per side at the bio-revitalization points.
- 04Cool compress + go-home
5 minute cool compress; immediate return to normal life.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| E40 Bio-Revitalizing HA (5 BRP) — Italian Hybrid HMW(this page) | Italian Hybrid High-Molecular-Weight HA — 5 Bio-Revitalization Points · Lift + Tighten + Hydrate · No-downtime · since 2015. | 30 minutes | Visible smoothing in 24 hours; firmness builds over 2 weeks; full result at 8–12 weeks. 2–3 sessions 4 weeks apart recommended for optimal ECM remodelling. Maintenance every 6 months. | From ฿8,500 | Patients seeking lift + tighten + hydration in one session |
| Wrinkle-Relax Injection | Wrinkle-relax injection for dynamic lines. | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | Forehead and frown lines |
| Volume Filler | Hyaluronic-acid volume restoration. | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | Cheek volume loss |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •Apply gentle moisturiser
- •SPF 50+ broad-spectrum daily — non-negotiable
- •Use only gentle cleanser 5 days
- •Stay hydrated
- •No retinoids / AHA / BHA 7 days
- •Avoid sun exposure 2 weeks
- •No sauna / hot bath 3 days
- •Avoid scrubbing / exfoliating 7 days
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦5 BRP technique — 5 single bio-revitalization points per side
- ✦Triple action: instant lifting + skin tightening + intense hydration
- ✦Hybrid HMW HA (Bio-Revitalizing) — not a filler, not a typical HA booster
- ✦Stimulates ECM (Extracellular Matrix) remodelling
- ✦Italian innovation since 2015 · CE marked · FDA-source materials
- ✦Visible smoothing in 24 hours; full result over 2–3 sessions
- ✦Excellent comfort score — patients describe minimal discomfort
What to expect
Visible smoothing in 24 hours; firmness builds over 2 weeks; full result at 8–12 weeks. 2–3 sessions 4 weeks apart recommended for optimal ECM remodelling. Maintenance every 6 months.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
E40 vs Profhilo — what's the difference?+
How is it different from a regular HA filler?+
How many sessions to see results?+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
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Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
Ready to talk it through? Let's begin.
A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.