E40 Bio-Revitalizing HA (5 BRP) — Italian Hybrid HMW
Italian hybrid high-molecular-weight HA, placed at 5 BRP points
The E40 Bio-Revitalizing HA treatment utilizes non-cross-linked High-Molecular-Weight Hyaluronic Acid (HMWHA) to stimulate ECM remodeling at the fibroblast level, resulting in instant lifting and skin tightening. This treatment is suitable for individuals seeking to improve skin hydration and elasticity.
The 5 BRPs deliver these effects in a 30-minute session, with minimal downtime. The price range begins at ฿8,500.
Available at the Waleerat Clinic in Bangkok. CE-marked and Thai-FDA approved for safety and efficacy.
- Category
- Skin Treatment
- Duration
- 30 minutes
- Downtime
- Little to none (rare bruising at injection points)
- Anaesthesia
- Topical (often not needed)
- Price (from)
- From ฿8,500
- Brands used
- E40 / 5 BRP / Bio Revitalizing HA
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Compatible (synthetic ingredients)
- Locations
- Siam Square One · BTS Siam Exit 3
E40 (Vitapharm / Medixa, Italy) is a Hybrid High-Molecular-Weight Hyaluronic Acid bio-revitalizer using non-cross-linked HMWHA technology. The signature 5 BRPs (Bio-Revitalization Points) deliver three simultaneous effects in a single session: instant lifting, skin tightening, and intense hydration — all by triggering ECM (Extracellular Matrix) remodelling at the fibroblast level.
CE-marked, FDA-source raw material, and ISO-certified manufacture. Marketed in Asia under Vitapharm.
Read more+
Developed in Italy since 2015.
Where it comes from, what's inside, who certifies it.
Hyaluronic acid is bio-fermented from Streptococcus zooepidemicus (bacterial source), not animal-derived. Major HA brands (Juvederm, Restylane) confirmed halal-compatible by LPPOM-MUI fatwa.
- Country of origin
- Italy
- Manufacturer
- Medixa srl (distributed in Asia by Vitapharm)
- Brands stocked
- E40 · 5 BRP · Bio Revitalizing HA
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- No — synthetic / bio-fermented source
- Lot-number shown to patient
- Yes — every vial, before injection
Italian-made Hybrid HMW HA bio-revitalizer. Non-cross-linked. CE marked since 2015. Distributed in Asia by Vitapharm.
- ✦Patients seeking lift + tighten + hydration in one session
- ✦Photoaged skin needing dermal restoration
- ✦First-time bio-revitalizer patients (gentler than Profhilo, no downtime)
- ✦Pre-event glow-up (skin firmness visible in 24h)
- 01Consultation
Physician assesses skin laxity and maps the 5 BRP injection points per side.
- 02Topical numbing (optional)
Cream applied 20 minutes prior — many patients skip and tolerate well.
- 035 BRP injections
5 precise micro-injections per side at the bio-revitalization points.
- 04Cool compress + go-home
5 minute cool compress; immediate return to normal life.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| E40 Bio-Revitalizing HA (5 BRP) — Italian Hybrid HMW(this page) | Italian hybrid high-molecular-weight HA, placed at 5 BRP points | 30 minutes | Visible smoothing in 24 hours; firmness builds over 2 weeks; full result at 8–12 weeks. 2–3 sessions 4 weeks apart recommended for optimal ECM remodelling. Maintenance every 6 months. | From ฿8,500 | Patients seeking lift + tighten + hydration in one session |
| Profhilo Bio-Remodelling | Hybrid hyaluronic acid bio-remodelling. | 45 minutes | Visible at 4 weeks. Protocol of 2 sessions, 1 month apart. Lasts 6 months. | From ฿22,999 / 1 bottle, 2cc | Skin laxity |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿8,999 / 100 Units | First-time Botox patients (entry tier) |
| Wrinkle-Relax Injection | Wrinkle-relax injection for dynamic lines. | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿9,999 / 100 Units (Neuronox) · ฿15,999 / 100 Units (Xeomin) · ฿19,999 / 100 Units (Allergan) | Forehead and frown lines |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦5 BRP technique — 5 single bio-revitalization points per side
- ✦Triple action: instant lifting + skin tightening + intense hydration
- ✦Hybrid HMW HA (Bio-Revitalizing) — not a filler, not a typical HA booster
- ✦Stimulates ECM (Extracellular Matrix) remodelling
- ✦Italian innovation since 2015 · CE marked · FDA-source materials
- ✦Visible smoothing in 24 hours; full result over 2–3 sessions
- ✦Excellent comfort score — patients describe minimal discomfort
What to expect
Visible smoothing in 24 hours; firmness builds over 2 weeks; full result at 8–12 weeks. 2–3 sessions 4 weeks apart recommended for optimal ECM remodelling. Maintenance every 6 months.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
Before you choose a clinic
A consultation is for deciding, not committing
Bring your goals, medical history, medicines and previous procedures. Ask for plain-language answers and take time to consider them before giving informed consent.
See the clinic-choice checklist →Ready to talk to our doctor?
Send a photo or describe your concern on LINE — we'll suggest a treatment plan and price range before you visit.
E40 vs Profhilo — what's the difference?+
How is it different from a regular HA filler?+
How many sessions to see results?+
Is E40 Bio-Revitalizing HA (5 BRP) — Italian Hybrid HMW halal-friendly?+
What happens during an E40 Bio-Revitalizing HA session?+
Who is a good candidate for E40 Bio-Revitalizing HA?+
2 more questions+
Does E40 Bio-Revitalizing HA hurt?+
What is the recovery like after E40 Bio-Revitalizing HA?+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
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Pregnant or breastfeeding — can I do this?+
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Still have questions?
CHAT ON LINEReady to talk it through? Let's begin.
A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.