Rejuran, Sculptra and Juvelook — what each one actually treats

01Understanding Rejuran, Sculptra, and Juvelook

When considering aesthetic treatments for skin rejuvenation, it's important to understand that different materials address distinct concerns. This article aims to clarify the differences between Rejuran (Korean Polynucleotide), Sculptra Volume Stimulator, and Juvelook PDLLA Skin Booster based on their underlying mechanisms and effects.

02Material-Based Treatments: Structure vs. Skin Quality

The choice of treatment often hinges on whether you are addressing structural volume loss or skin quality concerns such as texture, hydration, and brightness. Here's a breakdown of each product:

#### Rejuran (Korean Polynucleotide)

Price: From ฿6,500 / ampoule · ฿18,000 / 3-session program

Duration: 30–45 minutes per session

Downtime: Mild bruising + tiny papules for 3–5 days; full healing in 7–10 days

Rejuran is a Korean Polynucleotide (PN) Skin Booster from PharmaResearch. It uses purified salmon DNA fragments injected through mesotherapy to promote fibroblast activity and skin barrier repair.

PN molecules do not carry genetic information, ensuring safety for patients with concerns about DNA-based treatments. Rejuran comes in three formulations—skin quality, hydration, and eye area—and the physician will recommend the most suitable one based on your specific needs.

#### Sculptra Volume Stimulator

Price: From ฿25,000

Duration: 45 minutes

Downtime: Mild bruising for 2–3 days

Sculptra is a long-term collagen stimulant that places PLLA microspheres deep in the dermis. Over time, these microspheres gradually restore facial volume lost due to aging.

Volume builds gradually over 3 to 6 months, and the effect is generally maintained for up to two years.

#### Juvelook PDLLA Skin Booster

Price: From ฿1,999 / cc

Duration: 45 minutes

Downtime: Mild redness for a few hours; possible micro-bumps for 24–48 hours

Juvelook is a PDLLA (poly-D,L-lactic acid) microsphere skin booster. The PDLLA microspheres are injected into the dermis, where they stimulate fibroblasts to produce new collagen, gradually enhancing skin firmness, hydration, and radiance.

Juvelook is particularly effective for under-eye areas, helping to restore brightness without the volume increase associated with hyaluronic acid fillers.

03Choosing Between Rejuran, Sculptra, and Juvelook

Many patients combine treatments that address different aspects of their skin concerns because each material serves a distinct purpose. Here’s how they compare:

Rejuran: Focuses on repairing the skin barrier and improving overall skin quality through fibroblast activation.

Sculptra: Addresses structural volume loss by stimulating collagen production in deeper layers of the skin.

Juvelook: Enhances skin texture, hydration, and brightness without significant volume increase.

Since these treatments do not overlap entirely—Rejuran and Juvelook improve skin quality while Sculptra restores lost volume—it is common for patients to undergo one of each. This combination allows for a comprehensive approach to facial rejuvenation, addressing both superficial concerns like fine lines and deeper issues such as sagging and loss of definition.

04The Role of the Physician

The physician will assess your specific needs during consultation and recommend an appropriate treatment plan based on individual factors including skin condition, desired outcomes, and areas of concern. It is important to note that results vary between individuals due to differences in skin type, lifestyle, and overall health.

By understanding these distinctions, you can make informed decisions about which treatments best suit your aesthetic goals. Remember, the key to effective treatment lies in choosing a combination that addresses both structural volume loss and surface quality improvements.