- Duration
- Varies by the treatment area
- Recovery
- No single downtime is stated in the manufacturer sources reviewed
PLINEST & PLINEST fast — PN HPT Skin Quality Program
Fish-derived PN HPT from Mastelli, with PLINEST Program and PLINEST fast Program selected by treatment area rather than by the word ‘fast’.
- Category
- Skin Treatment
- Duration
- Varies by the treatment area
- Downtime
- No single downtime is stated in the manufacturer sources reviewed
- Brands used
- PLINEST / PLINEST fast
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Halal-friendly (ingredient-based; not certification)
- Locations
- Siam Square One · BTS Siam Exit 3
Quick answer: PLINEST Program and PLINEST fast Program are injectable PN HPT medical devices made by Mastelli in Italy; they are not HA volume fillers. The product material reviewed distinguishes PLINEST Program 40 mg/2 mL for the face from PLINEST fast Program 15 mg/2 mL for thin or delicate areas.
Both exact products have active Thai FDA import records. The choice is based on the area and the current labelled product, not on assuming PLINEST fast Program works faster or is stronger.
Where it comes from, what's inside, who certifies it.
Fish-derived PN HPT may be considered suitable by Muslim patients who accept fish-derived medical materials; no manufacturer Halal Certification was verified, and this is not a religious ruling.
- Country of origin
- Italy
- Manufacturer
- MASTELLI S.r.l.
- Brands stocked
- PLINEST · PLINEST fast
- Regulatory approvals
- EU CE
- Thai FDA · PLINEST · Active
- 67-2-1-2-0002773 — PLINEST POLYNUCLEOTIDES INTRADERMAL GEL
- Thai FDA · PLINEST fast · Active
- 67-2-1-2-0004272 — PLINEST FAST POLYNUCLEOTIDES INTRADERMAL GEL
- Animal-derived?
- Yes — see disclosure below
- Vegetarian-friendly
- No
PN HPT is extracted from trout gonads sourced from aquaculture serving the food market, according to Mastelli's 2024 sustainability report.
PLINEST and PLINEST fast are separate registered products. Confirm the exact labelled product before treatment; no price or universal result timeline is inferred from the manufacturer records.
- ✦People comparing a PN Program treatment with an HA Filler Program and wanting to avoid added volume
- ✦People who want the exact fish-derived ingredient origin disclosed before deciding
- ✦Muslim patients who regard fish-derived medical materials as acceptable and do not require a formal Halal certificate
- ✦People who want to verify the exact Thai FDA product record before treatment
- 01Match the concern to the area
The physician assesses whether the face or a thin, delicate area is being treated.
- 02Confirm the variant
Check the labelled box and syringe: PLINEST Program and PLINEST fast Program have separate Thai FDA records.
- 03Intradermal treatment
The manufacturer describes both as PN HPT gel for intradermal infiltration in a 2 mL pre-filled syringe.
- 04Receive area-specific aftercare
Recovery guidance is based on the area and injection plan rather than a universal timeline.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| PLINEST & PLINEST fast — PN HPT Skin Quality Program(this page) | Fish-derived PN HPT from Mastelli, with PLINEST Program and PLINEST fast Program selected by treatment area rather than by the word ‘fast’. | Varies by the treatment area | The manufacturer pages reviewed do not state one universal result timeline for every area. The page therefore does not promise a fixed onset, number of sessions or duration. | — | People comparing a PN Program treatment with an HA Filler Program and wanting to avoid added volume |
| Profhilo Bio-Remodelling Program | Hybrid hyaluronic acid bio-remodelling. | 45 minutes | Visible at 4 weeks. Protocol of 2 sessions, 1 month apart. Lasts 6 months. | From ฿10,000 | Skin laxity |
| Hutox Botulinum Toxin Type A (Korea) Program | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox Program brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | ฿3,000 | First-time Botox Program patients (entry tier) |
| Wrinkle-Relax Injection Program | Wrinkle-Relax Injection Program for dynamic lines. | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | ฿3,000 Neuronox or Hutox · ฿5,000 Xeomin · ฿8,000 Allergan | Forehead and frown lines |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦PLINEST Program 40 mg/2 mL is the face-focused variant in the product material reviewed
- ✦PLINEST fast Program 15 mg/2 mL is the lower-concentration variant for thin or delicate areas
- ✦The highlighted ingredient is Polynucleotides HPT derived from trout
- ✦Mastelli lists the PLINEST Program line as Class III medical devices with CE0373
- ✦The exact PLINEST Program and PLINEST fast Program Thai FDA records can be checked from this page
What to expect
The manufacturer pages reviewed do not state one universal result timeline for every area. The page therefore does not promise a fixed onset, number of sessions or duration.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
Before you choose a clinic
A consultation is for deciding, not committing
Bring your goals, medical history, medicines and previous procedures. Ask for plain-language answers and take time to consider them before giving informed consent.
See the clinic-choice checklist →Ready to talk to our doctor?
Send a photo or describe your concern on LINE — we'll suggest a treatment plan and price range before you visit.
What is the practical difference between PLINEST Program and PLINEST fast Program?+
What is the highlighted ingredient and where does it come from?+
Is PLINEST Program Halal-friendly?+
Is PLINEST Program Halal-certified?+
Are PLINEST Program and PLINEST fast Program registered with the Thai FDA?+
Does PLINEST Program contain hyaluronic acid?+
1 more questions+
Is PN HPT the same as PDRN Program?+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
Still have questions?
CHAT ON LINEReady to talk it through? Let's begin.
A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.