Guide · 2026·6 min read·2026-08-13

Dissolving filler — what hyaluronidase can and cannot undo

migratedfillerguide
In one paragraph

Hyaluronidase is a medical enzyme that can dissolve hyaluronic acid fillers but not other types of dermal fillers such as Radiesse or calcium hydroxylapatite. It's crucial to consult with a physician-supervised professional for a suitable course of action, especially when considering filler removal or correction.

Hyaluronidase Function
Breaks down hyaluronic acid fillers but not other types of dermal fillers.
Radiesse Breakdown
Naturally breaks down over several months without intervention.
Calcium Hydroxylapatite Fillers
Require alternative methods for correction, as they are not affected by hyaluronidase.
Professional Advice
Essential before any filler removal or correction procedure.

01Understanding Hyaluronidase

Hyaluronidase is an enzyme that can break down hyaluronic acid fillers, making it useful for correcting overfilled areas or removing unwanted effects. However, its effectiveness is limited to specific types of dermal fillers.

It's important to understand the limitations of hyaluronidase and seek professional advice before attempting any filler removal procedures.

02Dissolving Fillers: What Works?

While hyaluronidase can dissolve hyaluronic acid fillers, it is ineffective against other types of dermal fillers such as Radiesse or calcium hydroxylapatite. These require different approaches for correction.

Professional medical advice is essential to determine the most appropriate method for filler removal based on the type and location of the filler.

03Natural Breakdown of Fillers

Radiesse fillers are known to naturally break down over a period of several months, eliminating the need for hyaluronidase intervention in most cases.

Understanding how different types of fillers behave over time can help patients make informed decisions about their aesthetic treatments.

04Consultation and Professional Guidance

Before considering any filler removal or correction procedures, it is crucial to consult with a physician-supervised professional who can provide guidance based on the specific type of filler used.

Professional advice ensures that patients receive safe and effective treatment options tailored to their individual needs.

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05Common questions

Can hyaluronidase dissolve all types of dermal fillers?+
No, hyaluronidase is specific to hyaluronic acid fillers. It cannot dissolve other types such as Radiesse or calcium hydroxylapatite.
What happens if I want to remove a hyaluronic acid filler?+
If you wish to remove a hyaluronic acid filler, consulting with a physician-supervised professional is recommended. They can administer hyaluronidase or suggest alternative methods based on your specific needs.
How long does it take for Radiesse fillers to break down naturally?+
Radiesse fillers typically break down over several months, with most effects fading within 12-18 months. This natural breakdown eliminates the need for hyaluronidase in many cases.
What should I do if I have calcium hydroxylapatite fillers and want them removed?+
Calcium hydroxylapatite fillers require alternative methods for removal, as they are not affected by hyaluronidase. Consultation with a professional is necessary to determine a suitable course of action.
Why is it important to consult a physician before filler removal?+
Consulting a physician-supervised professional ensures that you receive safe and effective treatment tailored to your specific needs, reducing risks and ensuring optimal results.

07References & further reading

  1. Hyaluronidase for Dermal Filler Complications: Review of Applications and Dosage Recommendations

External sources · last verified 2026-08-13

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