Radiesse — CaHA Microsphere Biostimulator
Radiesse is the original calcium hydroxylapatite (CaHA) microsphere injectable from Merz Aesthetics (USA), used since 2003 in aesthetic medicine for collagen-stimulating volume restoration and dermal lift. CaHA microspheres act as scaffolding for fibroblast attachment, triggering Type I + Type III collagen production over 8–12 weeks. The microspheres are gradually metabolised over 18–24 months while the patient's own collagen scaffold remains. Halal-compatible — calcium hydroxylapatite is a synthetic mineral identical to the calcium-phosphate compound naturally found in bone. The carrier gel is methylcellulose-based (plant-derived). The closest comparable product is Reset Regenerative (also CaHA microsphere, pre-filled syringe variant); Radiesse is the original brand with the longer clinical-evidence record.

Radiesse — CaHA Microsphere Biostimulator — in a few minutes
5 key benefits
- 122-year clinical-evidence record (FDA approved 2003)
- 2Stimulates Type I + Type III collagen production over 8–12 weeks
- 3Effects last 18–24 months
- 4Halal-compatible — synthetic mineral active + plant-derived carrier
- 5Excellent for jawline definition + chin projection + nasolabial folds
Ideal for
4 steps · 30–45 minutes per session
- 1Consultation + planningAnatomical assessment, vector mapping, syringe count.
- 2Local anaesthesiaTopical + lidocaine pre-mix in the syringe; minimal discomfort.
- 3Microcannula injectionCannula-based injection in deep dermis along facial vectors.
- 4Massage + post-careGentle moulding by physician; ice as needed; settling visible 1–2 weeks.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
30 minutes with a licensed physician to assess if you're a candidate. If you're not, we'll tell you directly.
Questions to answer before choosing
Compare options by concern, goal and recovery window, then confirm suitability during an individual physician assessment.
Common questions
Radiesse vs Sculptra — which one for me?
Is Radiesse halal?
Will my face look unnatural?
Is Radiesse — CaHA Microsphere Biostimulator halal-friendly?
What happens during a Radiesse session?
Who is a good candidate for Radiesse?
3 more questions
Does Radiesse hurt?
What is the recovery like after Radiesse?
How many sessions before I see results?
Sculptra, Radiesse, Ellansé, Profhilo, Juvelook and Rejuran — how to choose
Sculptra, Radiesse and Ellansé are structural. They are placed deeper, and the body lays down its own collagen around the material. Sculptra is poly-L-lactic acid and works gradually — it adds nothing on the day. Radiesse is calcium hydroxylapatite and Ellansé is polycaprolactone; both carry a gel that occupies volume from the day of treatment, with the collagen result building behind it. Profhilo, Juvelook and Rejuran are skin treatments. Profhilo is a hybrid hyaluronic acid used to hydrate and remodel, Juvelook is a PDLLA booster for glow and firmness, and Rejuran is a purified salmon-derived polynucleotide used for repair and texture. Skin treatments do not replace lost volume, and structural products do not fix surface quality — many patients are treated with one of each rather than choosing between them.
Most patients start on the skin side, where the commitment is smaller. Juvelook has the lowest entry price of the six at ฿1,999 per cc, and Profhilo is a fixed two-session protocol a month apart. Structural work is the larger decision — a single Radiesse syringe starts at ฿15,000, Sculptra and Ellansé at ฿25,000 — and it is normally planned once the physician has assessed how much volume has actually been lost. Rejuran sits slightly apart from both: it is chosen for repair, meaning acne scarring and under-eye texture, rather than for glow or volume. Individual results vary.
- Mid-face or jawline that needs definition, without waiting months
- The calcium hydroxylapatite gel occupies volume from the day of treatment, and the collagen effect builds behind it over 8–12 weeks. Radiesse
- Diffuse volume loss, and you want the change to look gradual
- Poly-L-lactic acid adds nothing on the day — the volume is collagen you build over 3–6 months. Sculptra Volume Stimulator
- Volume restored and then held for as long as one product can
- Polycaprolactone carries volume from the day, and the collagen result reads at month 3–4 and holds roughly 12–18 months with variant S. Ellansé
- Skin that has lost firmness and glow — including neck and décolletage
- A fixed two-session protocol of hybrid hyaluronic acid, one month apart, visible from about four weeks. Profhilo Bio-Remodelling
- Dull, dehydrated skin, enlarged pores and early fine lines
- A PDLLA booster — brighter skin in around two weeks, with collagen-driven firmness peaking near eight. Juvelook
- Acne scarring, or under-eye skin that has gone crepey
- A purified salmon-derived polynucleotide used for repair, run as a three-session course at three-week intervals. Rejuran
| Sculptra Volume Stimulator | From ฿25,000 / 1 bottle | Mild bruising 2–3 days |
|---|---|---|
| Ellansé | From ฿25,000 / syringe (S grade) | Swelling or light bruising, usually 3–7 days; longer in a small proportion of patients |
| Profhilo Bio-Remodelling | From ฿22,999 / 1 bottle, 2cc | Mild swelling at injection points |
| Juvelook | From ฿15,999 / 1 bottle | Mild redness for a few hours; possible micro-bumps for 24–48 hours |
| Rejuran | From ฿9,999 / 2 cc | Mild bruising + tiny papules 3–5 days; full healing 7–10 days |
Other options in this category
Sculptra, Radiesse, Ellansé, Profhilo, Juvelook and Rejuran — how to chooseBook your consult via LINE @waleerat
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