- Harga
- From ฿18,999 (Strong 2cc)
- Tempoh
- 45 minutes
- Pemulihan
- Mild redness for a few hours
Nucleofill — Polynucleotide (PDRN) Rejuvenation Program
Gel polinukleotida Italiaan — regenerasi kulit pada tingkat sel melalui jalur 'kunci dan kunci' A2A.
- What is Nucleofill?
- The Nucleofill Program uses Polynucleotide (PN Program), extracted from DNA, to stimulate cellular skin repair, naturally enhancing skin structure strength.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿18,999 (Strong 2cc)
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Not suitable — animal-derived
- Locations
- Siam Square One · BTS Siam Exit 3
Nucleofill Program adalah gel injeksi polinukleotida (PDRN Program) yang diproduksi oleh Promoitalia (Italia), dengan sertifikasi CE. Polinukleotida adalah potongan DNA tingkat pembersihan tinggi yang diperoleh dari DNA sperma salmon liar; setelah diinjeksikan, mereka berfungsi sebagai 'kunci' yang cocok dengan 'kunci' receptor adenosine A2A pada permukaan sel, mendorong pertumbuhan fibroblast, jalur anti-inflamasi, perbaikan mikrokirculasi dan penyembuhan jaringan.
Ada empat varian — Medium, Strong, Soft Plus, dan Medium Plus — yang memungkinkan dokter menyesuaikan konsentrasi dan aliran sesuai dengan area, termasuk zona yang sensitif seperti bawah mata dan leher.
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦Pemuda kulit penuaan yang mencari perbaikan 'sejati' pada kulit, bukan volume
- ✦Bawah mata hitam di mana pengisian maya mungkin berisiko (efek Tyndall)
- ✦Rejuvenasi leher dan dada
- ✦Peradangan bekas jerawat dan tekstur tidak rata
- ✦Dukungan untuk kebotakan (injeksi pada kulit kepala)
- 01Konsultasi
Ahli memilih varian yang tepat (Medium / Strong / Soft Plus / Medium Plus) berdasarkan kondisi kulit dan area pengobatan.
- 02Anestesi
Anestesi topikal diterapkan selama 20 menit.
- 03Injeksi mikro
Gel polinucleotida diserahkan melalui injeksi dermal superfisial multiantit di area yang direncanakan.
- 04Ringkasan perawatan setelah
Penggunaan pendinginan, perawatan matahari dan panduan aktivitas 24 jam dibahas.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation Program(this page) | Gel polinukleotida Italiaan — regenerasi kulit pada tingkat sel melalui jalur 'kunci dan kunci' A2A. | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN Program gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿18,999 (Strong 2cc) | Pemuda kulit penuaan yang mencari perbaikan 'sejati' pada kulit, bukan volume |
| Profhilo Bio-Remodelling Program | Bio-remodelling asid hyaluronik hibrid. | 45 minutes | Visible at 4 weeks. Protocol of 2 sessions, 1 month apart. Lasts 6 months. | ฿22,999 / 1 syringe (2 ml) | Kendur kulit |
| Hutox Botulinum Toxin Type A (Korea) Program | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox Program brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | ฿3,000 | First-time Botox Program patients (entry tier) |
| Wrinkle-Relax Injection Program | Injeksi relaksan garisan untuk garis dinamik. | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | ฿3,000 Neuronox or Hutox · ฿5,000 Xeomin · ฿8,000 Allergan | Garis dahi dan frown |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Detailed guidance is shown in English while this locale awaits medical-language review.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦Regenerasi sel pada tingkat seluler melalui jalur A2A receptor
- ✦Manfaat anti-peradangan dan peningkatan mikrokirculasi
- ✦Mengaktifkan kolagen dan elastin tanpa menambah volume HA
- ✦Sesuai untuk zona yang sensitif — bawah mata, leher, dada, rambut kepala
Apa yang Anda Tunggu
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN Program gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
Keputusan individu berbeza. Hasil bergantung kepada umur, jenis kulit, anatomi, gaya hidup dan kepatuhan kepada rawatan selepasnya. Semua prosedur membawa risiko; maklumat risiko terperinci dibincangkan semasa konsultasi dan maklumat persetujuan yang telah ditandatangani diperoleh sebelum sebarang rawatan.
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Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
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Real questions from real customers — collated from chat conversations.
มีโปรโมชั่นอื่น ๆ ไหม?+
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Konsultasi bersama doktor berlangsung kira-kira 30–45 minit. Kami akan mendengar dahulu — membincangkan matlamat anda, kemudian memutuskan bersama sama adakah sebarang rawatan sesuai untuk anda.