Nucleofill — Polynucleotide (PDRN) Rejuvenation
意大利多核苷酸凝胶——通过A2A‘锁钥’通路实现细胞级皮肤再生。
- What is Nucleofill?
- The Nucleofill program uses Polynucleotide (PN), extracted from DNA, to stimulate cellular skin repair, naturally enhancing skin structure strength.
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿18,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Not suitable — animal-derived
- Locations
- Siam Square One · BTS Siam Exit 3
Nucleofill是一种由Promoitalia（意大利）制造的多核苷酸（PDRN）可注射凝胶，带有CE标志。多核苷酸是从野生三文鱼精子DNA中高度纯化的DNA片段；一旦注入，它们会作为‘钥匙’与细胞表面的腺苷A2A受体‘锁’结合，激活成纤维细胞增殖、抗炎途径、改善微循环和组织修复。有四种变体——Medium、Strong、Soft Plus 和 Medium Plus，让医生根据区域匹配浓度和流量，包括眼周和颈部等敏感区域。
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦全脸 rejuvenation 寻求‘真实皮肤改善’而非填充
- ✦眼部下方色斑，使用填充剂可能有风险（Tyndall 效应）
- ✦颈纹及胸部恢复
- ✦痤疮疤痕和纹理不均
- ✦头皮脱发支持（头皮注射）
- 01咨询
医生根据您的皮肤状况和治疗部位选择合适的变体（中度 / 强度 / 软加 / 中度加强）
- 02麻醉
使用局部麻醉剂20分钟后进行
- 03微注射
通过多点浅表真皮注射将聚核苷酸凝胶均匀地注入计划区域
- 04术后简要指导
介绍冷却、防晒和24小时活动指南
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | 意大利多核苷酸凝胶——通过A2A‘锁钥’通路实现细胞级皮肤再生。 | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿18,000 | 全脸 rejuvenation 寻求‘真实皮肤改善’而非填充 |
| Profhilo Bio-Remodelling | 生物重塑的混合透明质酸。 | 45 minutes | Visible at 4 weeks. Protocol of 2 sessions, 1 month apart. Lasts 6 months. | From ฿22,999 / 1 bottle, 2cc | 皮肤松弛 |
| Hutox Botulinum Toxin Type A (Korea) | 韩国 Huons BioPharma — 99.8% 纯度 · 4–6 个月持续时间 · 泰国食品药品监督管理局批准 · 易于获取的韩国 Botox 品牌。 | 15–20 minutes | 约 3–5 天起效，10–14 天达高峰，维持约 4–6 个月。个体差异存在，建议依医生建议安排回诊。 | From ฿8,999 / 100 Units | 首次尝试肉毒素者 |
| Wrinkle-Relax Injection | 皱纹舒缓注射，针对动态皱纹。 | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿9,999 / 100 Units (Neuronox) · ฿15,999 / 100 Units (Xeomin) · ฿19,999 / 100 Units (Allergan) | 眉间和眉皱 |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Detailed guidance is shown in English while this locale awaits medical-language review.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦细胞层面的再生通过A2A受体途径
- ✦抗炎和微循环益处
- ✦刺激胶原蛋白和弹性纤维而不增加HA体积
- ✦适用于敏感区域——眼周、颈部、锁骨下方、头皮
您可以期待什么
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
个人效果因人而异。结果取决于年龄、肤质、体格、生活方式和术后护理的坚持。所有治疗均存在风险；详细的风险信息将在咨询期间审查并获得签署的知情同意书。
选择诊所之前
咨询是为了做决定，而不是催促成交
准备好您的诉求、健康状况、用药和既往治疗记录。请对方用易懂的语言解释，并在签署知情同意前留出考虑时间。
查看选择诊所前的清单 →想直接和医生聊吗?
在LINE上发送照片或描述您的问题 — 我们会在您到访前推荐治疗方案和价格区间。
Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
推荐多少次疗程？+
需要做几次才能看到效果？+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
还有疑问?
在 LINE 上聊天Ready to talk it through? Let's begin.
医生咨询时长为30-45分钟。我们会先倾听——讨论您的目标，然后共同决定是否适合进行任何项目。