Nucleofill — Polynucleotide (PDRN) Rejuvenation
意大利多核苷酸凝胶——通过A2A‘锁钥’通路实现细胞级皮肤再生。
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿11,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Locations
- Siam Square One · Ekamai
Nucleofill是一种由Promoitalia（意大利）制造的多核苷酸（PDRN）可注射凝胶，带有CE标志。多核苷酸是从野生三文鱼精子DNA中高度纯化的DNA片段；一旦注入，它们会作为‘钥匙’与细胞表面的腺苷A2A受体‘锁’结合，激活成纤维细胞增殖、抗炎途径、改善微循环和组织修复。有四种变体——Medium、Strong、Soft Plus 和 Medium Plus，让医生根据区域匹配浓度和流量，包括眼周和颈部等敏感区域。
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦全脸 rejuvenation 寻求‘真实皮肤改善’而非填充
- ✦眼部下方色斑，使用填充剂可能有风险（Tyndall 效应）
- ✦颈纹及胸部恢复
- ✦痤疮疤痕和纹理不均
- ✦头皮脱发支持（头皮注射）
- 01咨询
医生根据您的皮肤状况和治疗部位选择合适的变体（中度 / 强度 / 软加 / 中度加强）
- 02麻醉
使用局部麻醉剂20分钟后进行
- 03微注射
通过多点浅表真皮注射将聚核苷酸凝胶均匀地注入计划区域
- 04术后简要指导
介绍冷却、防晒和24小时活动指南
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | 意大利多核苷酸凝胶——通过A2A‘锁钥’通路实现细胞级皮肤再生。 | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿11,000 | 全脸 rejuvenation 寻求‘真实皮肤改善’而非填充 |
| Wrinkle-Relax Injection | 皱纹舒缓注射，针对动态皱纹。 | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | 眉间和眉皱 |
| Volume Filler | 透明质酸体积恢复。 | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | 颧骨凹陷 |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •涂抹温和保湿霜
- •每日使用SPF50+广谱防晒——不可商量
- •仅使用温和洁面产品5天
- •保持充分水分
- •7天内不使用视黄醇/果酸/水杨酸
- •2周内避免日晒
- •3天内不使用桑拿/热水浴
- •7天内避免磨砂/去角质
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦细胞层面的再生通过A2A受体途径
- ✦抗炎和微循环益处
- ✦刺激胶原蛋白和弹性纤维而不增加HA体积
- ✦适用于敏感区域——眼周、颈部、锁骨下方、头皮
您可以期待什么
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
个人效果因人而异。结果取决于年龄、肤质、体格、生活方式和术后护理的坚持。所有治疗均存在风险；详细的风险信息将在咨询期间审查并获得签署的知情同意书。
Considering Nucleofill — Polynucleotide (PDRN) Rejuvenation?
Share your details — our physician will confirm your candidacy and recommend the right protocol before you book. No deposit required.
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在LINE上发送照片或描述您的问题 — 我们会在您到访前推荐治疗方案和价格区间。
Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
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Can I pay by credit card / 0% instalment?+
还有疑问?
在 LINE 上聊天Ready to talk it through? Let's begin.
30-45分钟的医生咨询是免费的。我们会先倾听——讨论您的目标，然后共同决定是否适合进行任何项目。