Nucleofill — Polynucleotide (PDRN) Rejuvenation
Italian polynucleotide gel — cellular-level skin regeneration via the A2A 'lock-and-key' pathway.
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
Nucleofill is a polynucleotide (PDRN) gel injectable made by Promoitalia (Italy), CE marked. Polynucleotides are highly purified DNA fragments derived from wild-salmon sperm DNA; once injected they act as a 'key' that fits the adenosine A2A receptor 'lock' on cell surfaces, activating fibroblast proliferation, anti-inflammatory pathways, improved microcirculation and tissue repair.
Four variants — Medium, Strong, Soft Plus and Medium Plus — let the physician match concentration and flow to the area, including delicate zones like under-eye and neck.
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦Full-face rejuvenation seeking 'real skin improvement', not volume
- ✦Under-eye dark circles where filler may be risky (Tyndall effect)
- ✦Neck and decolletage rejuvenation
- ✦Acne scars and uneven texture
- ✦Hair-thinning support (scalp injections)
- 01Consultation
Physician selects the appropriate variant (Medium / Strong / Soft Plus / Medium Plus) for your skin condition and treatment area.
- 02Numbing
Topical anaesthetic applied for 20 minutes.
- 03Micro-injection
Polynucleotide gel delivered by multi-point superficial dermal injection across the planned area.
- 04Aftercare brief
Cooling, sun-care and 24-hour activity guidance reviewed.
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai, English, 中文, 日本語, 한국어, العربية, Bahasa Melayu, Español, Русский — written and spoken at consultation.
Siam Square One (BTS Siam, opposite Paragon) + Ekamai (BTS Ekamai, Sukhumvit). Walk-in distance, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation(this page) | Italian polynucleotide gel — cellular-level skin regeneration via the A2A 'lock-and-key' pathway. | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿11,000 | Full-face rejuvenation seeking 'real skin improvement', not volume |
| Wrinkle-Relax Injection | Wrinkle-relax injection for dynamic lines. | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | From ฿3,000 (Hutox/Neuronox) · ฿5,000 (Xeomin) · ฿8,000 (Allergan) | Forehead and frown lines |
| Volume Filler | Hyaluronic-acid volume restoration. | 30 minutes | Immediate. Lasts 9–18 months depending on product and area. | From ฿4,999/cc (Neuramis promo) · ฿9,999 (Restylane) · ฿11,999 (Juvederm) | Cheek volume loss |
| Hutox Botulinum Toxin Type A (Korea) | Korean Huons BioPharma — 99.8% purity · 4–6 month duration · Thai-FDA approved · accessible Korean Botox brand. | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | From ฿3,000 | First-time Botox patients (entry tier) |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
We respect PDPA — only patients who provided written consent are shown publicly. Ask to see consented case examples privately during consultation.
- •Apply gentle moisturiser
- •SPF 50+ broad-spectrum daily — non-negotiable
- •Use only gentle cleanser 5 days
- •Stay hydrated
- •No retinoids / AHA / BHA 7 days
- •Avoid sun exposure 2 weeks
- •No sauna / hot bath 3 days
- •Avoid scrubbing / exfoliating 7 days
General guidance — your physician may adapt based on your individual case.
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
Ekamai branch — standalone clinic near BTS Ekamai on the Sukhumvit corridor. Japanese-speaking concierge (Omotenashi). On-site parking.
- ●BTS Ekamai4m
- ●Gateway Ekamai6m
- ●Major Cineplex Ekamai6m
- ●Park Hyatt Bangkok12m
- ●EmQuartier14m
- ●EmSphere15m
- ✦Cellular-level regeneration via the A2A receptor pathway
- ✦Anti-inflammatory and microcirculation benefits
- ✦Stimulates collagen and elastin without adding HA volume
- ✦Suitable for delicate zones — under-eye, neck, decolletage, scalp
- ✦Four variants tunable to skin condition (Medium / Strong / Soft Plus / Medium Plus)
What to expect
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
Individual results vary. Outcomes depend on age, skin type, anatomy, lifestyle and adherence to aftercare. All procedures carry risk; detailed risk information is reviewed during consultation and signed informed consent is obtained before any treatment.
Real questions from real customers — answered by our physicians
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Ready to talk it through? Let's begin.
A 30–45 minute physician consultation is complimentary. We'll listen first — discuss your goals, then decide together whether any procedure is right for you.