Nucleofill — Polynucleotide (PDRN) Rejuvenation Program
意大利多核苷酸凝膠——通過A2A『鎖鑰』通路實現細胞級皮膚再生。
- What is Nucleofill?
- The Nucleofill Program uses Polynucleotide (PN Program), extracted from DNA, to stimulate cellular skin repair, naturally enhancing skin structure strength.
Illustrative image, AI-generated, not an actual patient · Individual results vary
Nucleofill is a polynucleotide (PDRN) gel injectable used for cellular-level skin regeneration. It works by delivering purified DNA fragments from salmon, activating fibroblast proliferation and improving microcirculation through the A2A receptor pathway.
Suitable for individuals seeking to address signs of aging and promote tissue repair. Results are typically noticeable within 4-6 weeks with a treatment duration of 45 minutes and minimal downtime (mild redness for a few hours).
The price starts from ฿11,000 at Waleerat Clinic in Bangkok. This CE-marked treatment is approved for use in Thailand.
- Category
- Skin Treatment
- Duration
- 45 minutes
- Downtime
- Mild redness for a few hours
- Anaesthesia
- Topical
- Price (from)
- From ฿18,000
- Brands used
- Nucleofill / Nucleofill Strong / Nucleofill Soft Plus / Nucleofill Medium Plus
- Country of origin
- Italy
- Regulatory
- Thai FDA · CE
- Halal compatibility
- Not suitable — animal-derived
- Locations
- Siam Square One · BTS Siam Exit 3
Nucleofill是一種由Promoitalia（意大利）製造的多核苷酸（PDRN Program）可注射凝膠，帶有CE標誌。 多核苷酸是從野生三文魚精子DNA中高度純化的DNA片段；一旦注入，它們會作為『鑰匙』與細胞表面的腺苷A2A受體『鎖』結合，激活成纖維細胞增殖、抗炎途徑、改善微循環和組織修復。
有四種變體——Medium、Strong、Soft Plus 和 Medium Plus，讓醫生根據區域匹配濃度和流量，包括眼周和頸部等敏感區域。
Where it comes from, what's inside, who certifies it.
Salmon DNA / polynucleotides (PN). Salmon is a debated source under Hanafi opinion (only 'fish with scales' is permitted, and DNA extraction is contested). NOT halal under the strict opinion most GCC patients follow.
- Country of origin
- Italy
- Manufacturer
- Promoitalia
- Brands stocked
- Nucleofill · Nucleofill Strong · Nucleofill Soft Plus · Nucleofill Medium Plus
- Regulatory approvals
- EU CEThai FDA / อย.
- Animal-derived?
- Yes — see disclosure below
- Lot-number shown to patient
- Yes — every vial, before injection
Polynucleotides (PDRN) sourced from highly purified wild-salmon sperm DNA
PDRN is salmon-derived; not halal-certified. Lot number on each pre-filled syringe is shown to the patient before injection.
- ✦全臉 rejuvenation 尋求『真實皮膚改善』而非填充
- ✦眼部下方色斑，使用填充劑可能有風險（Tyndall 效應）
- ✦頸紋及胸部恢復
- ✦痤瘡疤痕和紋理不均
- ✦頭皮脫髮支持（頭皮注射）
- 01諮詢
醫生根據您的皮膚狀況和治療部位選擇合適的變體（中度 / 強度 / 軟加 / 中度加強）
- 02麻醉
使用局部麻醉劑20分鐘後進行
- 03微注射
通過多點淺表真皮注射將聚核苷酸凝膠均勻地注入計劃區域
- 04術後簡要指導
介紹冷卻、防曬和24小時活動指南
Compare our pricing with anyone — here is what you get that's different.
Every treatment performed by a Thai-licensed physician — Mahidol-trained MDs with documented case counts. No nurse-injectors.
Show me the lot. Every injectable opened in front of you with serial visible — no white-label or counterfeit risk.
Our injectables and devices pass at least one major regulator's filing. Provenance is published on every service page.
Thai and English are spoken by all clinical staff. 中文, 日本語, 한국어 and العربية are covered by an on-call medical translator, arranged when you request it at booking.
Siam Square One, at BTS Siam Exit 3 opposite Siam Paragon. Walk-in distance from the platform, no driving stress.
Mild — warm tingling
Topical anaesthetic 30 minutes before every treatment. Anxiolytics available on request. Your physician adapts technique to your sensitivity level.
Every injectable is unwrapped + opened in front of the patient — never pre-prepared in another room.
Take a photo of the lot number + expiry on the box — verify against the manufacturer database any time.
Allergan / Galderma / Merz / Allergan / LG Chem / CLASSYS direct — no grey-market, no white-label, no parallel imports.
Consent form names the exact brand + lot. If we substitute, we re-consent on the spot.
Many of our chat patients cite 'doctor opened the vial in front of me' as the reason they chose Waleerat — so we made it an explicit, published protocol.
137 first-time patients asked this in chat — so we wrote it as a checklist.
- •NSAIDs (ibuprofen, aspirin) — 5 days prior
- •Fish oil, vitamin E, garlic, ginkgo — 5 days prior
- •Alcohol — 24 hours prior
- •Heavy facial massage / sauna — 24 hours prior
- •Government photo ID
- •List of current medications + supplements
- •Reference photos (Instagram saves work great)
- •Sunglasses — easy on the eyes after numbing
Click any concern for a detailed explainer.
| Treatment | Mechanism | Duration | Results last | Price | Best for |
|---|---|---|---|---|---|
| Nucleofill — Polynucleotide (PDRN) Rejuvenation Program(this page) | 意大利多核苷酸凝膠——通過A2A『鎖鑰』通路實現細胞級皮膚再生。 | 45 minutes | Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN Program gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary. | From ฿18,000 | 全臉 rejuvenation 尋求『真實皮膚改善』而非填充 |
| Profhilo Bio-Remodelling Program | 生物重塑的混合透明質酸。 | 45 minutes | Visible at 4 weeks. Protocol of 2 sessions, 1 month apart. Lasts 6 months. | From ฿22,999 / 1 bottle, 2cc | 皮膚鬆弛 |
| Hutox Botulinum Toxin Type A (Korea) Program | 韓國 Huons BioPharma — 99.8% 純度 · 4–6 個月持續時間 · 泰國食品藥品監督管理局批准 · 易於獲取的韓國 Botox Program 品牌。 | 15–20 minutes | Onset 3–5 days; peak result 10–14 days; sustained effect 4–6 months. Maintenance every 4–6 months for continuous results. | ฿3,000 | First-time Botox Program patients (entry tier) |
| Wrinkle-Relax Injection Program | 皺紋舒緩注射，針對動態皺紋。 | 15–20 minutes | Onset 3–7 days, peak at 14 days. Lasts 3–4 months. | ฿3,000 Neuronox or Hutox · ฿5,000 Xeomin · ฿8,000 Allergan | 眉間和眉皺 |
Comparative information only — individual results vary. Please consult a licensed physician before deciding.
Asian patients (HK, China, Singapore, Japan) often stack treatments in one visit for efficiency. Your physician will tailor a program in your consultation.
Research-informed guidance for this treatment type. Your doctor’s written plan after assessment always takes priority.
Detailed guidance is shown in English while this locale awaits medical-language review.
Before your appointment
- Tell the doctor about allergies, infection or inflammation, bleeding tendency, medicines and supplements, immune conditions, prior implants or filler, and pregnancy or breastfeeding.
- Confirm the exact product and whether the treatment plan requires product-specific massage; do not assume all biostimulators have the same aftercare.
After treatment
- Keep the sites clean and avoid pressing or massage unless the written product-specific plan instructs it.
- Use gentle skincare and ask when to resume makeup, exercise, heat exposure and active products.
- Keep the product record and attend the planned review.
What may be expected
- Temporary bumps, swelling, redness, tenderness or bruising may occur; the expected timeline differs by formulation and injection depth.
Contact us promptly
- Contact the clinic for persistent nodules, increasing heat or redness, drainage, fever, or delayed inflammation.
- Seek urgent care for unusual pain, marked skin-colour change, vision change or neurological symptoms.
1:1 follow-up
Before you leave, the team records your treatment, expected recovery, follow-up timing and direct contact path. A doctor reviews concerns when needed.
Evidence and patient information
- U.S. Food and Drug Administration: Dermal Fillers (Soft Tissue Fillers)
- Dermatologic Surgery: Consensus Recommendations for Combined Aesthetic Interventions Using Calcium Hydroxylapatite
- Journal of Cosmetic Dermatology: Clinical Experience with Polycaprolactone-Based Dermal Filler Complications
- Journal of Cosmetic Dermatology: Consensus report on the use of PN-HPT in aesthetic medicine
Siam Square One flagship — opposite Siam Paragon, skywalk from BTS Siam Exit 3, in the CBD heart of Bangkok (Pathum Wan). 1-minute walk from BTS.
- ●BTS Siam (Exit 3)1m
- ●Siam Paragon2m
- ●Siam Discovery3m
- ●Siam Center3m
- ●Siam Kempinski Hotel4m
- ●MBK Center5m
- ●Chulalongkorn University8m
- ✦細胞層面的再生通過A2A受體途徑
- ✦抗炎和微循環益處
- ✦刺激膠原蛋白和彈性纖維而不增加HA體積
- ✦適用於敏感區域——眼周、頸部、鎖骨下方、頭皮
您可以期待什麼
Immediate hydration within 1–2 hours; metabolic activation around 48 hours; PDRN Program gradually metabolised over 7–15 days while cellular repair benefits continue. Recommended protocol: 3–4 sessions, 2–4 weeks apart, with maintenance every 6–12 months. Individual results vary.
個人效果因人而異。結果取決於年齡、膚質、體格、生活方式和術後護理的堅持。所有治療均存在風險；詳細的風險信息將在諮詢期間審查並獲得籤署的知情同意書。
選擇診所之前
諮詢是為了做決定，而不是催促成交
準備好您的訴求、健康狀況、用藥和既往療程紀錄。請對方用易懂的語言解釋，並在簽署知情同意前留出考慮時間。
查看選擇診所前的清單 →Ready to talk to our doctor?
Send a photo or describe your concern on LINE — we'll suggest a treatment plan and price range before you visit.
Real questions from real customers — answered by our physicians
Rejuran คืออะไร — ราคา Rejuran I, S, HB ที่วลีรัตน์+
Rejuran ใต้ตาช่วยเรื่องอะไร+
推薦多少次療程？+
需要做幾次才能看到效果？+
Real questions from real customers — collated from chat conversations.
Are there other promotions?+
How much does it cost — is there a promo?+
How long does the treatment take?+
Are there side effects?+
Where is the clinic?+
How long do results last?+
Does it hurt?+
Pregnant or breastfeeding — can I do this?+
Can I go home immediately / how many days off work?+
Translation support for Chinese / Japanese / Korean / English?+
How do I book — is rush appointment available?+
Can I pay by credit card / 0% instalment?+
Still have questions?
CHAT ON LINEReady to talk it through? Let's begin.
醫生諮詢時長為30-45分鐘。我們會先傾聽——討論您的目標，然後共同決定是否適合進行任何項目。